Marc Symons Selected Research

semapimod

10/2016	Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion.
1/2015	The Macrophage Inhibitor CNI-1493 Blocks Metastasis in a Mouse Model of Ewing Sarcoma through Inhibition of Extravasation.
1/2014	Semapimod sensitizes glioblastoma tumors to ionizing radiation by targeting microglia.

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Marc Symons Research Topics

Disease

28	Neoplasms (Cancer) 01/2021 - 05/2002
15	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 11/2004
12	Glioma (Gliomas) 01/2020 - 11/2004
9	Neoplasm Metastasis (Metastasis) 01/2020 - 05/2003
5	Brain Neoplasms (Brain Tumor) 01/2021 - 01/2016
4	Carcinoma (Carcinomatosis) 01/2020 - 04/2003
4	Medulloblastoma 01/2017 - 08/2009
3	Breast Neoplasms (Breast Cancer) 01/2015 - 03/2004
3	Astrocytoma (Pilocytic Astrocytoma) 02/2014 - 01/2008
2	Ewing Sarcoma (Sarcoma, Ewing) 10/2015 - 01/2015
1	Leukemia 10/2020
1	Osteosarcoma (Osteogenic Sarcoma) 01/2020
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2017
1	Oligodendroglioma 01/2017
1	Sepsis (Septicemia) 01/2017
1	Primitive Neuroectodermal Tumors (PNET) 01/2011
1	Melanoma (Melanoma, Malignant) 01/2009
1	Rheumatoid Arthritis 05/2007
1	Carcinogenesis 11/2005
1	Inflammation (Inflammations) 06/2005

Drug/Important Bio-Agent (IBA)

7	Monomeric GTP-Binding ProteinsIBA 02/2014 - 11/2005
6	Small Interfering RNA (siRNA)IBA 01/2016 - 11/2004
5	GTP Phosphohydrolases (GTPases)IBA 01/2020 - 11/2005
4	Proteins (Proteins, Gene)FDA Link 10/2020 - 10/2012
4	synaptojaninIBA 01/2015 - 04/2003
3	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 10/2020 - 12/2008
3	Gefitinib (Iressa)FDA Link 01/2020 - 10/2016
3	Protein Kinases (Protein Kinase)IBA 01/2020 - 10/2012
3	Epidermal Growth Factor (EGF)IBA 01/2017 - 09/2007
3	Mebendazole (Anti-Worm)FDA Link 01/2017 - 02/2015
3	Pharmaceutical PreparationsIBA 01/2017 - 01/2014
3	semapimodIBA 10/2016 - 01/2014
3	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 02/2014 - 03/2004
2	ErbB Receptors (EGF Receptor)IBA 01/2021 - 01/2015
2	Temozolomide (Temodar)FDA LinkGeneric 01/2021 - 10/2018
2	Biological ProductsIBA 01/2021 - 01/2016
2	MicroRNAs (MicroRNA)IBA 01/2021 - 01/2015
2	Rho Guanine Nucleotide Exchange FactorsIBA 11/2020 - 10/2018
2	Matrix Metalloproteinases (MMPs)IBA 01/2020 - 01/2013
2	Peptide Hydrolases (Proteases)FDA Link 01/2020 - 01/2013
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2015 - 11/2012
2	Phosphatidylinositols (Phosphatidylinositol)IBA 11/2012 - 09/2007
2	ClathrinIBA 11/2012 - 04/2003
2	matrigelIBA 10/2005 - 11/2004
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2021
1	Bevacizumab (Avastin)FDA Link 11/2020
1	rhoC GTP-Binding ProteinIBA 10/2020
1	Receptor-Interacting Protein Serine-Threonine Kinase 2 (CARDIAK)IBA 01/2020
1	N 30IBA 01/2018
1	Factor VIII (Coagulation Factor VIII)IBA 01/2017
1	AnthelminticsIBA 01/2017
1	Leucine (L-Leucine)FDA Link 01/2017
1	N-Formylmethionine (Formylmethionine, N)IBA 01/2017
1	Discoidin Domain ReceptorsIBA 01/2017
1	Peptides (Polypeptides)IBA 01/2017
1	Phenylalanine (L-Phenylalanine)FDA Link 01/2017
1	Pemetrexed (MTA)FDA Link 01/2017
1	Vincristine (Oncovin)FDA LinkGeneric 01/2017
1	milk fat globuleIBA 01/2017
1	CurcuminIBA 12/2016
1	pexidartinibIBA 10/2016
1	polycarbonateIBA 10/2016
1	4- cyano- N- (2- (1- cyclohexen- 1- yl)- 4- (1- ((dimethylamino)acetyl)- 4- piperidinyl)phenyl)- 1H- imidazole- 2- carboxamideIBA 10/2016
1	VaccinesIBA 01/2016
1	CesiumIBA 01/2016
1	ProdrugsIBA 01/2016
1	Celecoxib (Celebrex)FDA Link 10/2015
1	LipidsIBA 01/2015
1	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 02/2014
1	Phosphotransferases (Kinase)IBA 02/2013
1	lysophosphatidic acidIBA 02/2013
1	A-Form DNA (A-DNA)IBA 10/2012
1	VimentinIBA 01/2011
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2011
1	rac1 GTP-Binding ProteinIBA 08/2009
1	GuanosineIBA 08/2009
1	OligonucleotidesIBA 12/2008
1	blebbistatinIBA 01/2008
1	Myosin Light Chains (Myosin Essential Light Chain)IBA 01/2008
1	Myosin Type IIIBA 01/2008
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 10/2006
1	NF-kappa B (NF-kB)IBA 10/2006
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2006
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 10/2006
1	CC ChemokinesIBA 06/2005
1	Cyclin D1IBA 05/2003
1	CyclinsIBA 05/2003
1	RNA (Ribonucleic Acid)IBA 04/2003
1	SurvivinIBA 05/2002

Therapy/Procedure

12	Therapeutics 01/2021 - 07/2006
5	Radiotherapy 01/2020 - 01/2013
1	Intravenous Administration 01/2021
1	Surgical Amputation (Amputations) 01/2018
1	Ligation 01/2017
1	Punctures 01/2017
1	Brachytherapy 01/2016
1	Drug Therapy (Chemotherapy) 05/2002